InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIMP1

Summary

InnateDB Protein

IDBP-375577.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIMP1

Protein Name

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

Synonyms

EMAP2; EMAPII; HLD3; p43; SCYE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000405248

InnateDB Gene

IDBG-33233 (AIMP1)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269PubMed:10358004, ECO:0000269PubMed:11157763, ECO:0000269PubMed:11306575, ECO:0000269PubMed:11818442, ECO:0000269PubMed:12237313, ECO:0000269PubMed:19362550}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.

Disease Associations

Leukodystrophy, hypomyelinating, 3 (HLD3) [MIM:260600]: A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system. {ECO:0000269PubMed:21092922}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	42 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006006	glucose metabolic process
GO:0006418	tRNA aminoacylation for protein translation
GO:0006915	apoptotic process
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009611	response to wounding
GO:0010467	gene expression
GO:0016192	vesicle-mediated transport
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0009986	cell surface
GO:0016020	membrane
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex
GO:0030133	transport vesicle