Version 5.4
Homo sapiens Protein: FADS1
Summary
InnateDB Protein IDBP-375823.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FADS1
Protein Name fatty acid desaturase 1
Synonyms D5D; FADS6; FADSD5; LLCDL1; TU12;
Species Homo sapiens
Ensembl Protein ENSP00000405087
InnateDB Gene IDBG-50478 (FADS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000248 C-5 sterol desaturase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0007267 cell-cell signaling
GO:0008654 phospholipid biosynthetic process
GO:0009267 cellular response to starvation
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0043651 linoleic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045595 regulation of cell differentiation
GO:0046456 icosanoid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR005804 Fatty acid desaturase, type 1
PFAM PF00487
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60427
PhosphoSite PhosphoSite-O60427
TrEMBL I3ZNT3
UniProt Splice Variant
Entrez Gene 3992
UniGene Hs.651782
RefSeq
HUGO HGNC:3574
OMIM 606148
CCDS
HPRD 06935
IMGT
EMBL AC004770 AF084558 AF199596 AF226273 AK027427 AK027522 AK074754 AK074819 AK096275 AK222906 AK289552 AK314199 AL512760 AL834479 AP002380 BC007846 JQ773028 JQ773029 JQ773030 JQ773031 JQ773032 JQ773033 JQ773034 JQ773035 JQ773036 JQ773037 JQ773038 JQ773039 JQ773040 JQ773041 JQ773042 JQ773043 JQ773044 JQ773045 JQ773046 JQ773047 JQ773048 JQ773049 JQ773050 JQ773051 JQ773052 JQ773053 JQ773054 JQ773055 JQ773056 JQ773057 JQ773058 JQ773059 JQ773061 JQ773062 JQ773063 JQ773064 JQ773065 JQ773066 JQ773067 JQ773068 JQ773069 JQ773070 JQ773071 JQ773072 JQ773073 JQ773074 JQ773075 JQ773076 JQ773077 JQ773078 JQ773079 JQ773080 JQ773081 JQ773082 JQ773084 JQ773085 JQ773086 JQ773087 JQ773088 JQ773089 JQ773090 JQ773091 JQ773092 JQ773093 JQ773094 JQ773095 JQ773096 JQ773097 JQ773098 JQ773099 JQ773100 JQ773101 JQ773102 JQ773103 JQ773104 JQ773105 JQ773106 JQ773107 JQ773108 JQ773109 JQ773110 JQ773111 JQ773112 JQ773113 JQ773114 JQ773115 JQ773116 JQ773117 JQ773118 JQ773119 JQ773120 JQ773121 JQ773122 JQ773123 JQ773124 JQ773125 JQ773126 JQ773127 JQ773128 JQ773129 JQ773130 JQ773131 JQ773132 JQ773133 JQ773134 JQ773135 JQ773136 JQ773137 JQ773138 JQ773139 JQ773140 JQ773141 JQ773142 JQ773200 JQ773201 JQ773202 JQ773203 JQ773204 JQ773205 JQ773206 JQ773207 JQ773208 JQ773209 JQ773210 JQ773211 JQ773212 JQ773213 JQ773214 JQ773215 JQ773216 JQ773217 JQ773218 JQ773219 JQ773220 JQ773221 JQ773222 JQ773223 JQ773224 JQ773225 JQ773226 JQ773227 JQ773228 JQ773229 JQ773230 JQ773231 JQ773232 JQ773233 JQ773234 JQ773235 JQ773236 JQ773237 JQ773238 JQ773239 JQ773240 JQ773241 JQ773242 JQ773243 JQ773244 JQ773245 JQ773246 JQ773247 JQ773248 JQ773249 JQ773250 JQ773251 JQ773252 JQ773253 JQ773254 JQ773255 JQ773256 JQ773257 JQ773258 JQ773259 JQ773260
GenPept AAC23397 AAF29378 AAF70457 AAG23120 AAH07846 AFL91514 AFL91515 AFL91516 AFL91517 AFL91518 AFL91519 AFL91520 AFL91521 AFL91522 AFL91523 AFL91524 AFL91525 AFL91526 AFL91527 AFL91528 AFL91529 AFL91530 AFL91531 AFL91532 AFL91533 AFL91534 AFL91535 AFL91536 AFL91537 AFL91538 AFL91539 AFL91540 AFL91541 AFL91542 AFL91543 AFL91544 AFL91545 AFL91547 AFL91548 AFL91549 AFL91550 AFL91551 AFL91552 AFL91553 AFL91554 AFL91555 AFL91556 AFL91557 AFL91558 AFL91559 AFL91560 AFL91561 AFL91562 AFL91563 AFL91564 AFL91565 AFL91566 AFL91567 AFL91568 AFL91570 AFL91571 AFL91572 AFL91573 AFL91574 AFL91575 AFL91576 AFL91577 AFL91578 AFL91579 AFL91580 AFL91581 AFL91582 AFL91583 AFL91584 AFL91585 AFL91586 AFL91587 AFL91588 AFL91589 AFL91590 AFL91591 AFL91592 AFL91593 AFL91594 AFL91595 AFL91596 AFL91597 AFL91598 AFL91599 AFL91600 AFL91601 AFL91602 AFL91603 AFL91604 AFL91605 AFL91606 AFL91607 AFL91608 AFL91609 AFL91610 AFL91611 AFL91612 AFL91613 AFL91614 AFL91615 AFL91616 AFL91617 AFL91618 AFL91619 AFL91620 AFL91621 AFL91622 AFL91623 AFL91624 AFL91625 AFL91626 AFL91627 AFL91628 AFL91629 AFL91630 AFL91631 AFL91632 AFL91633 AFL91634 AFL91635 AFL91636 AFL91637 AFL91638 AFL91639 AFL91640 AFL91641 AFL91642 AFL91643 AFL91644 AFL91645 AFL91646 AFL91647 AFL91648 AFL91649 AFL91650 AFL91651 AFL91652 AFL91653 AFL91654 AFL91655 AFL91656 AFL91657 AFL91658 AFL91659 AFL91660 AFL91661 AFL91662 AFL91663 AFL91664 AFL91665 AFL91666 AFL91667 AFL91668 AFL91669 AFL91670 AFL91671 AFL91672 AFL91673 AFL91674 AFL91675 AFL91676 AFL91677 AFL91678 AFL91679 AFL91680 AFL91681 AFL91682 AFL91683 AFL91684 AFL91685 AFL91686 AFL91687 AFL91688 AFL91689 BAB55103 BAB55173 BAC11182 BAC11229 BAD96626 BAF82241 BAG36877 BAG53244 CAC21679 CAD39138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca