Homo sapiens Gene: FADS1
Summary
InnateDB Gene IDBG-50478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FADS1
Gene Name fatty acid desaturase 1
Synonyms D5D; FADS6; FADSD5; LLCDL1; TU12;
Species Homo sapiens
Ensembl Gene ENSG00000149485
Encoded Proteins
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
fatty acid desaturase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61799625-61829318
Strand Reverse strand
Band q12.2
Transcripts
ENST00000350997 ENSP00000322229
ENST00000433932 ENSP00000405087
ENST00000424501 ENSP00000407895
ENST00000421879 ENSP00000416043
ENST00000448607 ENSP00000391229
ENST00000460649 ENSP00000445253
ENST00000496123
ENST00000491310 ENSP00000429016
ENST00000466716 ENSP00000446270
ENST00000473263 ENSP00000445442
ENST00000536991 ENSP00000439097
ENST00000542506 ENSP00000441403
ENST00000539999 ENSP00000443587
ENST00000540767 ENSP00000441871
ENST00000545245 ENSP00000442170
ENST00000545405 ENSP00000440652
ENST00000544696 ENSP00000443037
ENST00000544309 ENSP00000439790
ENST00000539419 ENSP00000438997
ENST00000541683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000248 C-5 sterol desaturase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037 heme binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008654 phospholipid biosynthetic process
GO:0009267 cellular response to starvation
GO:0009744 response to sucrose stimulus
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0019369 arachidonic acid metabolic process
GO:0032868 response to insulin
GO:0033189 response to vitamin A
GO:0033559 unsaturated fatty acid metabolic process
GO:0035900 response to isolation stress
GO:0036109 alpha-linolenic acid metabolic process
GO:0043651 linoleic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045595 regulation of cell differentiation
GO:0046456 icosanoid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
alpha-linolenic acid (ALA) metabolism pathway
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
Linoleic acid (LA) metabolism pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Biosynthesis of unsaturated fatty acids pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503546 Hs.651782
RefSeq NM_013402
HUGO
OMIM
CCDS CCDS8011
HPRD 06935
IMGT
EMBL
GenPept
RNA Seq Atlas