Version 5.4
Homo sapiens Protein: FBXO32
Summary
InnateDB Protein IDBP-376011.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO32
Protein Name F-box protein 32
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000390790
InnateDB Gene IDBG-34790 (FBXO32)
Protein Structure
UniProt Annotation
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. {ECO:0000269PubMed:15531760}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:22249105}. Nucleus {ECO:0000269PubMed:22249105}. Note=Shuttles between Cytoplasm and the nucleus.
Disease Associations
Tissue Specificity Specifically expressed in cardiac and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 124 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016567 protein ubiquitination
Cellular Component
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969P5
PhosphoSite PhosphoSite-Q969P5
TrEMBL
UniProt Splice Variant
Entrez Gene 114907
UniGene Hs.708951
RefSeq NP_001229392
HUGO HGNC:16731
OMIM 606604
CCDS CCDS56553
HPRD 05966
IMGT
EMBL AC090193 AJ420108 AK056986 AY059629 EF143260
GenPept AAL16407 ABO37797 BAB71333 CAD12251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca