Version 5.4
Homo sapiens Gene: FBXO32
Summary
InnateDB Gene IDBG-34790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO32
Gene Name F-box protein 32
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156804
Encoded Proteins
IDBP-376011
F-box protein 32
IDBP-480115
F-box protein 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123497889-123541206
Strand Reverse strand
Band q24.13
Transcripts
ENST00000287396
ENST00000443022 ENSP00000390790
ENST00000517956 ENSP00000428205
ENST00000524000
ENST00000521719
ENST00000520511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 124 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016567 protein ubiquitination
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005730 nucleolus
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022358
View Gene Order
ENSBTAG00000016194
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
foxopathway
FoxO family signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.403933 Hs.594942 Hs.596630 Hs.708951
RefSeq NM_001242463 NM_058229 NM_148177
HUGO
OMIM
CCDS CCDS56553 CCDS6345
HPRD 05966
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca