Homo sapiens Gene: FBXO32
Summary
InnateDB Gene IDBG-34790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO32
Gene Name F-box protein 32
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156804
Encoded Proteins
F-box protein 32
F-box protein 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123497889-123541206
Strand Reverse strand
Band q24.13
Transcripts
ENST00000287396
ENST00000443022 ENSP00000390790
ENST00000517956 ENSP00000428205
ENST00000524000
ENST00000521719
ENST00000520511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 124 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016567 protein ubiquitination
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005730 nucleolus
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
FoxO family signaling
Cross-References
SwissProt Q969P5
TrEMBL A0A024R9F3 Q0VAQ6 Q498Y9
UniProt Splice Variant
Entrez Gene 114907
UniGene Hs.403933 Hs.594942 Hs.596630 Hs.708951
RefSeq NM_058229 NM_148177 NM_001242463
HUGO HGNC:16731
OMIM 606604
CCDS CCDS6345 CCDS56553
HPRD 05966
IMGT
EMBL AC090193 AJ420108 AK056986 AY059629 BC100020 BC120963 BC120964 CH471060 EF143260
GenPept AAI00021 AAI20964 AAI20965 AAL16407 ABO37797 BAB71333 CAD12251 EAW92042 EAW92043
RNA Seq Atlas 114907