Version 5.4
Homo sapiens Protein: TRIM36
Summary
InnateDB Protein IDBP-37603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM36
Protein Name tripartite motif containing 36
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368938
InnateDB Gene IDBG-37599 (TRIM36)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. {ECO:0000269PubMed:15145053}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0051726 regulation of cell cycle
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005856 cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQ86
PhosphoSite PhosphoSite-Q9NQ86
TrEMBL
UniProt Splice Variant
Entrez Gene 55521
UniGene Hs.624202
RefSeq NP_001017397
HUGO HGNC:16280
OMIM 609317
CCDS CCDS34211
HPRD 15554
IMGT
EMBL AC008494 AC094104 AJ272269 AK296389 AK316422 BC045164 BC046096 BC130334 BX460627 CH471086
GenPept AAH45164 AAH46096 AAI30335 BAH12340 BAH14793 CAB94831 EAW48972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca