InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STMN1

Summary

InnateDB Protein

IDBP-376095.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STMN1

Protein Name

stathmin 1

Synonyms

C1orf215; Lag; LAP18; OP18; PP17; PP19; PR22; SMN;

Species

Homo sapiens

Ensembl Protein

ENSP00000387858

InnateDB Gene

IDBG-94424 (STMN1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. {ECO:0000269PubMed:12676564, ECO:0000269PubMed:1917919}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0015631	tubulin binding

Biological Process

GO:0007019	microtubule depolymerization
GO:0007052	mitotic spindle organization
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0035556	intracellular signal transduction