Homo sapiens Gene: STMN1
Summary
InnateDB Gene IDBG-94424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STMN1
Gene Name stathmin 1
Synonyms C1orf215; Lag; LAP18; OP18; PP17; PP19; PR22; SMN;
Species Homo sapiens
Ensembl Gene ENSG00000117632
Encoded Proteins
stathmin 1
stathmin 1
stathmin 1
stathmin 1
stathmin 1
stathmin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Stmn1 overexpression impacts microtubule stability, impairs cell spreading, reduces activation-associated phenotypes andreduces complement receptor 3 (CR3)-mediated phagocytosis and cellular activation.
Entrez Gene
Summary This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:25884181-25906991
Strand Reverse strand
Band p36.11
Transcripts
ENST00000357865 ENSP00000350531
ENST00000374291 ENSP00000363409
ENST00000399728 ENSP00000382633
ENST00000426559 ENSP00000410452
ENST00000455785 ENSP00000387858
ENST00000446334 ENSP00000407567
ENST00000513116
ENST00000465604
ENST00000485226
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0015631 tubulin binding
Biological Process
GO:0007019 microtubule depolymerization
GO:0007052 mitotic spindle organization
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0009615 response to virus
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031115 negative regulation of microtubule polymerization
GO:0035556 intracellular signal transduction
GO:0051272 positive regulation of cellular component movement
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSLP pathway
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
PID NCI
Signaling mediated by p38-gamma and p38-delta
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.209983 Hs.606995 Hs.714380
RefSeq NM_001145454 NM_005563 NM_203399 NM_203401
HUGO
OMIM
CCDS CCDS269 CCDS44090
HPRD 01047
IMGT
EMBL
GenPept
RNA Seq Atlas