InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STMN1

Summary

InnateDB Gene

IDBG-94424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STMN1

Gene Name

stathmin 1

Synonyms

C1orf215; Lag; LAP18; OP18; PP17; PP19; PR22; SMN

Species

Homo sapiens

Ensembl Gene

ENSG00000117632

Encoded Proteins

IDBP-94428

stathmin 1

IDBP-94432

stathmin 1

IDBP-229968

stathmin 1

IDBP-376089

stathmin 1

IDBP-376095

stathmin 1

IDBP-376099

stathmin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26082487

[Mus musculus] Stmn1 overexpression impacts microtubule stability, impairs cell spreading, reduces activation-associated phenotypes andreduces complement receptor 3 (CR3)-mediated phagocytosis and cellular activation.

Entrez Gene

Summary

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:25884181-25906991

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000357865	ENSP00000350531
ENST00000374291	ENSP00000363409
ENST00000399728	ENSP00000382633
ENST00000426559	ENSP00000410452
ENST00000455785	ENSP00000387858
ENST00000446334	ENSP00000407567
ENST00000513116
ENST00000465604
ENST00000485226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0015631	tubulin binding

Biological Process

GO:0007019	microtubule depolymerization
GO:0007052	mitotic spindle organization
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0009615	response to virus
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0035556	intracellular signal transduction
GO:0051272	positive regulation of cellular component movement

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028832

View Gene Order

ENSBTAG00000013761

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

P16949

TrEMBL

A2A2D0

UniProt Splice Variant

Entrez Gene

3925

UniGene

Hs.209983 Hs.606995 Hs.714380

RefSeq

NM_001145454 NM_005563 NM_203399 NM_203401

HUGO

HGNC:6510

OMIM

151442

CCDS

CCDS269 CCDS44090

HPRD

01047

IMGT

EMBL

AK303692 AK311801 AL033528 BC082228 CH471059 J04991 M31303 X53305 X94912 Z11566

GenPept

AAA59971 AAA59980 AAH82228 BAG34744 BAH14020 CAA37391 CAA64398 CAA77660 CAC16020 EAX07854 EAX07855 EAX07856 EAX07857 EAX07858 EAX07859 EAX07860

RNA Seq Atlas

3925