Homo sapiens Protein: PFKFB4
Summary
InnateDB Protein IDBP-376116.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB4
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000407657
InnateDB Gene IDBG-32970 (PFKFB4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0016311 dephosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003094 Fructose-2,6-bisphosphatase
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PF01591
PRINTS PR00991
PIRSF PIRSF000709
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9K0D8
UniProt Splice Variant
Entrez Gene 5210
UniGene Hs.476217
RefSeq
HUGO HGNC:8875
OMIM 605320
CCDS
HPRD 05613
IMGT
EMBL AC134772
GenPept