Version 5.4
Homo sapiens Gene: PFKFB4
Summary
InnateDB Gene IDBG-32970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB4
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114268
Encoded Proteins
IDBP-32972
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-32974
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376100
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376106
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376110
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376116
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376122
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
IDBP-376126
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48517684-48562015
Strand Reverse strand
Band p21.31
Transcripts
ENST00000232375 ENSP00000232375
ENST00000383734 ENSP00000373240
ENST00000416568 ENSP00000388394
ENST00000445633 ENSP00000400772
ENST00000417753 ENSP00000389169
ENST00000452531 ENSP00000407657
ENST00000412035 ENSP00000393047
ENST00000422701 ENSP00000415764
ENST00000490115
ENST00000478516
ENST00000468162
ENST00000471890
ENST00000496767
ENST00000490404
ENST00000467176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025648
View Gene Order
ENSBTAG00000006752
Not yet available
Pathways
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JX77 Q66S35
UniProt Splice Variant
Entrez Gene 5210
UniGene Hs.476217
RefSeq NM_004567
HUGO HGNC:8875
OMIM 605320
CCDS CCDS2771
HPRD 05613
IMGT
EMBL AC134772 AY707863
GenPept AAU11326
RNA Seq Atlas 5210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca