InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTSS1

Summary

InnateDB Protein

IDBP-376144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTSS1

Protein Name

metastasis suppressor 1

Synonyms

MIM; MIMA; MIMB;

Species

Homo sapiens

Ensembl Protein

ENSP00000393606

InnateDB Gene

IDBG-35101 (MTSS1)

Protein Structure

UniProt Annotation

Function

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. {ECO:0000269PubMed:12082544}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding

Biological Process

GO:0006928	cellular component movement
GO:0007009	plasma membrane organization
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0030035	microspike assembly
GO:0030036	actin cytoskeleton organization
GO:0046847	filopodium assembly
GO:0050680	negative regulation of epithelial cell proliferation
GO:0061333	renal tubule morphogenesis
GO:0071498	cellular response to fluid shear stress
GO:0072102	glomerulus morphogenesis
GO:0072160	nephron tubule epithelial cell differentiation
GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis