InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R8

Summary

InnateDB Protein

IDBP-377195.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R8

Protein Name

protein phosphatase 1, regulatory subunit 8

Synonyms

ARD-1; ARD1; NIPP-1; NIPP1; PRO2047;

Species

Homo sapiens

Ensembl Protein

ENSP00000410206

InnateDB Gene

IDBG-95029 (PPP1R8)

Protein Structure

UniProt Annotation

Function

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Subcellular Localization

Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. {ECO:0000269PubMed:10103062, ECO:0000269PubMed:7499293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.