Version 5.4
Homo sapiens Protein: LSM14A
Summary
InnateDB Protein IDBP-377352.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM14A
Protein Name LSM14A, SCD6 homolog A (S. cerevisiae)
Synonyms C19orf13; FAM61A; RAP55; RAP55A;
Species Homo sapiens
Ensembl Protein ENSP00000413964
InnateDB Gene IDBG-547325 (LSM14A)
Protein Structure
UniProt Annotation
Function Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. {ECO:0000269PubMed:16484376, ECO:0000269PubMed:17074753}.
Subcellular Localization Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
GO:0007275 multicellular organismal development
GO:0033962 cytoplasmic mRNA processing body assembly
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR010920 Like-Sm (LSM) domain
IPR019050 FDF domain
PFAM PF09532
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8ND56
PhosphoSite PhosphoSite-Q8ND56
TrEMBL
UniProt Splice Variant
Entrez Gene 26065
UniGene Hs.729627
RefSeq NP_001107565
HUGO HGNC:24489
OMIM 610677
CCDS CCDS46040
HPRD 12697
IMGT
EMBL AB069974 AB069975 AK027369 AK027643 AL117499 AL834398 BC016842
GenPept AAH16842 BAB55066 BAB55259 BAC99045 BAC99046 CAB55964 CAD39060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca