InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPI

Summary

InnateDB Protein

IDBP-377432.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPI

Protein Name

glucose-6-phosphate isomerase

Synonyms

AMF; GNPI; NLK; PGI; PHI; SA-36; SA36;

Species

Homo sapiens

Ensembl Protein

ENSP00000405573

InnateDB Gene

IDBG-42902 (GPI)

Protein Structure

UniProt Annotation

Function

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. {ECO:0000269PubMed:11004567, ECO:0000269PubMed:11437381}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11437381}. Secreted {ECO:0000269PubMed:11437381}.

Disease Associations

Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]: A form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004347	glucose-6-phosphate isomerase activity
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0016866	intramolecular transferase activity
GO:0048029	monosaccharide binding

Biological Process

GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006959	humoral immune response
GO:0007599	hemostasis
GO:0007611	learning or memory
GO:0019242	methylglyoxal biosynthetic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0046185	aldehyde catabolic process
GO:0051156	glucose 6-phosphate metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome