InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPI

Summary

InnateDB Gene

IDBG-42902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPI

Gene Name

glucose-6-phosphate isomerase

Synonyms

AMF; GNPI; NLK; PGI; PHI; SA-36; SA36

Species

Homo sapiens

Ensembl Gene

ENSG00000105220

Encoded Proteins

IDBP-42904

glucose-6-phosphate isomerase

IDBP-377432

glucose-6-phosphate isomerase

IDBP-763028

IDBP-765295

IDBP-760223

IDBP-760214

IDBP-760797

IDBP-763673

IDBP-764830

IDBP-764757

IDBP-764547

IDBP-763626

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:34359480-34402156

Strand

Forward strand

Band

q13.11

Transcripts

ENST00000356487	ENSP00000348877
ENST00000415930	ENSP00000405573
ENST00000586392
ENST00000592277	ENSP00000466191
ENST00000588991	ENSP00000465858
ENST00000586425	ENSP00000467670
ENST00000587384	ENSP00000468298
ENST00000589640	ENSP00000467590
ENST00000589504
ENST00000587521	ENSP00000464797
ENST00000591204	ENSP00000466851
ENST00000590362
ENST00000592144	ENSP00000464798
ENST00000589985
ENST00000586077
ENST00000590375	ENSP00000467221
ENST00000589399	ENSP00000468201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004347	glucose-6-phosphate isomerase activity
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0016866	intramolecular transferase activity
GO:0048029	monosaccharide binding

Biological Process

GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006959	humoral immune response
GO:0007599	hemostasis
GO:0007611	learning or memory
GO:0019242	methylglyoxal biosynthetic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0046185	aldehyde catabolic process
GO:0051156	glucose 6-phosphate metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome