Homo sapiens Gene: GPI
Summary
InnateDB Gene IDBG-42902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPI
Gene Name glucose-6-phosphate isomerase
Synonyms AMF; GNPI; NLK; PGI; PHI; SA-36; SA36;
Species Homo sapiens
Ensembl Gene ENSG00000105220
Encoded Proteins
glucose-6-phosphate isomerase
glucose-6-phosphate isomerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34359480-34402156
Strand Forward strand
Band q13.11
Transcripts
ENST00000356487 ENSP00000348877
ENST00000415930 ENSP00000405573
ENST00000586392
ENST00000592277 ENSP00000466191
ENST00000588991 ENSP00000465858
ENST00000586425 ENSP00000467670
ENST00000587384 ENSP00000468298
ENST00000589640 ENSP00000467590
ENST00000589504
ENST00000587521 ENSP00000464797
ENST00000591204 ENSP00000466851
ENST00000590362
ENST00000592144 ENSP00000464798
ENST00000589985
ENST00000586077
ENST00000590375 ENSP00000467221
ENST00000589399 ENSP00000468201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004347 glucose-6-phosphate isomerase activity
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0016866 intramolecular transferase activity
GO:0048029 monosaccharide binding
Biological Process
GO:0001525 angiogenesis
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006959 humoral immune response
GO:0007599 hemostasis
GO:0007611 learning or memory
GO:0019242 methylglyoxal biosynthetic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044281 small molecule metabolic process
GO:0046185 aldehyde catabolic process
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Starch and sucrose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
Fructose Mannose metabolism pathway
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL K7ENA0
UniProt Splice Variant
Entrez Gene 2821
UniGene Hs.466471 Hs.740140
RefSeq NM_000175 NM_001184722 NM_001289790 XM_005258764 XM_006723148
HUGO HGNC:4458
OMIM 172400
CCDS CCDS12437 CCDS54246
HPRD 01394
IMGT
EMBL AC010504 AC092073
GenPept
RNA Seq Atlas 2821