InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAD

Summary

InnateDB Protein

IDBP-37748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAD

Protein Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264705

InnateDB Gene

IDBG-37744 (CAD)

Protein Structure

UniProt Annotation

Function

This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). {ECO:0000269PubMed:24332717}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15890648}. Nucleus {ECO:0000269PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	54 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004070	aspartate carbamoyltransferase activity
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151	dihydroorotase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016597	amino acid binding
GO:0016743	carboxyl- or carbamoyltransferase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070335	aspartate binding

Biological Process

GO:0001889	liver development
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006541	glutamine metabolic process
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0014075	response to amine
GO:0017144	drug metabolic process
GO:0018107	peptidyl-threonine phosphorylation
GO:0031000	response to caffeine
GO:0031100	organ regeneration
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0046777	protein autophosphorylation
GO:0051414	response to cortisol
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0070409	carbamoyl phosphate biosynthetic process
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002082 Aspartate carbamoyltransferase
IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR006130 Aspartate/ornithine carbamoyltransferase
IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
IPR006274 Carbamoyl-phosphate synthase, small subunit
IPR006275 Carbamoyl-phosphate synthase, large subunit
IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011607 Methylglyoxal synthase-like domain
IPR011761 ATP-grasp fold
IPR016185 Pre-ATP-grasp domain
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like

PFAM