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InnateDB Protein
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IDBP-377807.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VPS54
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Protein Name
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vacuolar protein sorting 54 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414725
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InnateDB Gene
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IDBG-53799 (VPS54)
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Protein Structure
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| Function |
May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269PubMed:18367545}.
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| Subcellular Localization |
Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:18367545}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
5
[view]
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| Protein-Protein |
5
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
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| Biological Process |
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GO:0042147
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retrograde transport, endosome to Golgi
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR012501
Vps54-like
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| PFAM |
PF07928
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9P1Q0
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
51542
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| UniGene |
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| RefSeq |
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| HUGO |
HGNC:18652
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| OMIM |
614633
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| CCDS |
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| HPRD |
10302
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4