Version 5.4
Homo sapiens Gene: VPS54
Summary
InnateDB Gene IDBG-53799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS54
Gene Name vacuolar protein sorting 54 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143952
Encoded Proteins
IDBP-53801
vacuolar protein sorting 54 homolog (S. cerevisiae)
IDBP-53803
vacuolar protein sorting 54 homolog (S. cerevisiae)
IDBP-292991
vacuolar protein sorting 54 homolog (S. cerevisiae)
IDBP-377807
vacuolar protein sorting 54 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63892146-64019072
Strand Reverse strand
Band p14
Transcripts
ENST00000272322 ENSP00000272322
ENST00000354504 ENSP00000346499
ENST00000409558 ENSP00000386980
ENST00000416400 ENSP00000414725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0040007 growth
GO:0042147 retrograde transport, endosome to Golgi
GO:0048873 homeostasis of number of cells within a tissue
GO:0050881 musculoskeletal movement
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0000938 GARP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020128
View Gene Order
ENSBTAG00000000115
Not yet available
Cross-References
SwissProt Q9P1Q0
TrEMBL
UniProt Splice Variant
Entrez Gene 51542
UniGene
RefSeq NM_001005739 NM_016516
HUGO HGNC:18652
OMIM 614633
CCDS CCDS33208 CCDS46302
HPRD
IMGT
EMBL AF102177 AK002205 AL137604 AL359939 AY444798 BC030275 BC041868 CR749701
GenPept AAF37319 AAH30275 AAH41868 AAS20945 BAA92134 CAB70837 CAB95772 CAH18479
RNA Seq Atlas 51542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca