Version 5.4
Homo sapiens Protein: GPRASP1
Summary
InnateDB Protein IDBP-378148.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPRASP1
Protein Name G protein-coupled receptor associated sorting protein 1
Synonyms GASP; GASP-1; GASP1;
Species Homo sapiens
Ensembl Protein ENSP00000393691
InnateDB Gene IDBG-80321 (GPRASP1)
Protein Structure
UniProt Annotation
Function Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. {ECO:0000269PubMed:12142540, ECO:0000269PubMed:15452121, ECO:0000269PubMed:23954414}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15452121}.
Disease Associations
Tissue Specificity Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. {ECO:0000269PubMed:12142540, ECO:0000269PubMed:15086532}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0008333 endosome to lysosome transport
GO:1990172 G-protein coupled receptor catabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006911 Armadillo repeat-containing domain
IPR016024 Armadillo-type fold
PFAM PF04826
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JY77
PhosphoSite PhosphoSite-Q5JY77
TrEMBL
UniProt Splice Variant
Entrez Gene 9737
UniGene Hs.729265
RefSeq NP_001092880
HUGO HGNC:24834
OMIM 300417
CCDS CCDS35352
HPRD 02333
IMGT
EMBL AB007903 AL035427 AY044233 BC114552
GenPept AAI14553 AAK95578 BAA23715 CAB55683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca