Homo sapiens Gene: GPRASP1
Summary
InnateDB Gene IDBG-80321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPRASP1
Gene Name G protein-coupled receptor associated sorting protein 1
Synonyms GASP; GASP-1; GASP1;
Species Homo sapiens
Ensembl Gene ENSG00000198932
Encoded Proteins
G protein-coupled receptor associated sorting protein 1
G protein-coupled receptor associated sorting protein 1
G protein-coupled receptor associated sorting protein 1
G protein-coupled receptor associated sorting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:102651366-102659083
Strand Forward strand
Band q22.1
Transcripts
ENST00000361600 ENSP00000355146
ENST00000415986 ENSP00000393691
ENST00000444152 ENSP00000409420
ENST00000466098
ENST00000537097 ENSP00000445683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0008333 endosome to lysosome transport
GO:1990172 G-protein coupled receptor catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.729265
RefSeq NM_001099410 NM_001099411 NM_001184727 NM_014710
HUGO
OMIM
CCDS CCDS35352
HPRD 02333
IMGT
EMBL
GenPept
RNA Seq Atlas