Version 5.4
Homo sapiens Gene: GPRASP1
Summary
InnateDB Gene IDBG-80321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPRASP1
Gene Name G protein-coupled receptor associated sorting protein 1
Synonyms GASP; GASP-1; GASP1
Species Homo sapiens
Ensembl Gene ENSG00000198932
Encoded Proteins
IDBP-80323
G protein-coupled receptor associated sorting protein 1
IDBP-378148
G protein-coupled receptor associated sorting protein 1
IDBP-378150
G protein-coupled receptor associated sorting protein 1
IDBP-602540
G protein-coupled receptor associated sorting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:102651366-102659083
Strand Forward strand
Band q22.1
Transcripts
ENST00000361600 ENSP00000355146
ENST00000415986 ENSP00000393691
ENST00000444152 ENSP00000409420
ENST00000466098
ENST00000537097 ENSP00000445683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0008333 endosome to lysosome transport
GO:1990172 G-protein coupled receptor catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q5JY77
TrEMBL
UniProt Splice Variant
Entrez Gene 9737
UniGene Hs.729265
RefSeq NM_001099410 NM_001099411 NM_001184727 NM_014710
HUGO HGNC:24834
OMIM 300417
CCDS CCDS35352
HPRD
IMGT
EMBL AB007903 AL035427 AY044233 BC114552
GenPept AAI14553 AAK95578 BAA23715 CAB55683
RNA Seq Atlas 9737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca