InnateDB Protein
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IDBP-378150.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPRASP1
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Protein Name
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G protein-coupled receptor associated sorting protein 1
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Synonyms
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GASP; GASP-1; GASP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409420
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InnateDB Gene
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IDBG-80321 (GPRASP1)
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Protein Structure
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Function |
Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. {ECO:0000269PubMed:12142540, ECO:0000269PubMed:15452121, ECO:0000269PubMed:23954414}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15452121}.
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Disease Associations |
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Tissue Specificity |
Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. {ECO:0000269PubMed:12142540, ECO:0000269PubMed:15086532}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
54
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006911
Armadillo repeat-containing domain
IPR016024
Armadillo-type fold
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PFAM |
PF04826
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5JY77
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PhosphoSite |
PhosphoSite-Q5JY77
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9737
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UniGene |
Hs.729265
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RefSeq |
NP_001092881
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HUGO |
HGNC:24834
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OMIM |
300417
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CCDS |
CCDS35352
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HPRD |
02333
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IMGT |
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EMBL |
AB007903
AL035427
AY044233
BC114552
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GenPept |
AAI14553
AAK95578
BAA23715
CAB55683
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