InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNOT1

Summary

InnateDB Protein

IDBP-378336.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT1

Protein Name

CCR4-NOT transcription complex, subunit 1

Synonyms

CDC39; NOT1; NOT1H;

Species

Homo sapiens

Ensembl Protein

ENSP00000413113

InnateDB Gene

IDBG-34466 (CNOT1)

Protein Structure

UniProt Annotation

Function

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269PubMed:10637334, ECO:0000269PubMed:16778766, ECO:0000269PubMed:21278420, ECO:0000269PubMed:21976065, ECO:0000269PubMed:21984185, ECO:0000269PubMed:22367759, ECO:0000269PubMed:23644599}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:21976065}. Nucleus {ECO:0000305PubMed:21976065}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. {ECO:0000269PubMed:10637334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0042974	retinoic acid receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031047	gene silencing by RNA
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036	regulation of stem cell maintenance

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0030014	CCR4-NOT complex