Version 5.4
Homo sapiens Gene: CNOT1
Summary
InnateDB Gene IDBG-34466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT1
Gene Name CCR4-NOT transcription complex, subunit 1
Synonyms CDC39; NOT1; NOT1H
Species Homo sapiens
Ensembl Gene ENSG00000125107
Encoded Proteins
IDBP-34468
CCR4-NOT transcription complex, subunit 1
IDBP-34470
CCR4-NOT transcription complex, subunit 1
IDBP-378336
CCR4-NOT transcription complex, subunit 1
IDBP-746176
IDBP-750090
IDBP-753132
IDBP-752378
IDBP-749526
IDBP-745635
IDBP-753108
IDBP-746476
IDBP-746428
IDBP-750013
IDBP-752204
IDBP-753443
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:58519951-58629886
Strand Reverse strand
Band q21
Transcripts
ENST00000317147 ENSP00000320949
ENST00000245138 ENSP00000245138
ENST00000441024 ENSP00000413113
ENST00000567285 ENSP00000458057
ENST00000569916
ENST00000563130
ENST00000567133 ENSP00000454763
ENST00000569263
ENST00000569732
ENST00000565697 ENSP00000455289
ENST00000568158
ENST00000563283
ENST00000569020 ENSP00000457869
ENST00000566240 ENSP00000457173
ENST00000569882 ENSP00000454377
ENST00000568917 ENSP00000454611
ENST00000567188 ENSP00000456649
ENST00000570139
ENST00000569924
ENST00000564557 ENSP00000456975
ENST00000562046 ENSP00000456131
ENST00000569240 ENSP00000455635
ENST00000565605 ENSP00000457460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005488 binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0042974 retinoic acid receptor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006417 regulation of translation
GO:0007275 multicellular organismal development
GO:0010467 gene expression
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036550
View Gene Order
ENSBTAG00000020782
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460923 Hs.742212
RefSeq NM_001265612 NM_016284 NM_206999
HUGO
OMIM
CCDS CCDS10799 CCDS45501 CCDS58468
HPRD 11999
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca