Homo sapiens Gene: CNOT1
Summary
InnateDB Gene IDBG-34466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT1
Gene Name CCR4-NOT transcription complex, subunit 1
Synonyms CDC39; NOT1; NOT1H;
Species Homo sapiens
Ensembl Gene ENSG00000125107
Encoded Proteins
CCR4-NOT transcription complex, subunit 1
CCR4-NOT transcription complex, subunit 1
CCR4-NOT transcription complex, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:58519951-58629886
Strand Reverse strand
Band q21
Transcripts
ENST00000317147 ENSP00000320949
ENST00000245138 ENSP00000245138
ENST00000441024 ENSP00000413113
ENST00000567285 ENSP00000458057
ENST00000569916
ENST00000563130
ENST00000567133 ENSP00000454763
ENST00000569263
ENST00000569732
ENST00000565697 ENSP00000455289
ENST00000568158
ENST00000563283
ENST00000569020 ENSP00000457869
ENST00000566240 ENSP00000457173
ENST00000569882 ENSP00000454377
ENST00000568917 ENSP00000454611
ENST00000567188 ENSP00000456649
ENST00000570139
ENST00000569924
ENST00000564557 ENSP00000456975
ENST00000562046 ENSP00000456131
ENST00000569240 ENSP00000455635
ENST00000565605 ENSP00000457460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005488 binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0042974 retinoic acid receptor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006417 regulation of translation
GO:0007275 multicellular organismal development
GO:0010467 gene expression
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Deadenylation-dependent mRNA decay pathway
Deadenylation of mRNA pathway
Gene Expression pathway
KEGG
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460923 Hs.742212
RefSeq NM_001265612 NM_016284 NM_206999
HUGO
OMIM
CCDS CCDS10799 CCDS45501 CCDS58468
HPRD 11999
IMGT
EMBL
GenPept
RNA Seq Atlas