InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGRMC2

Summary

InnateDB Protein

IDBP-37858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGRMC2

Protein Name

progesterone receptor membrane component 2

Synonyms

DG6; PMBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000296425

InnateDB Gene

IDBG-37856 (PGRMC2)

Protein Structure

UniProt Annotation

Function

Receptor for steroids. {ECO:0000305}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003707	steroid hormone receptor activity
GO:0005496	steroid binding
GO:0020037	heme binding

Biological Process

GO:0043401

steroid hormone mediated signaling pathway

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001199 Cytochrome b5-like heme/steroid binding domain

PFAM

PF00173

PRINTS

PR00363

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15173

PhosphoSite

PhosphoSite-O15173

TrEMBL

D3DNX8

UniProt Splice Variant

Entrez Gene

10424

UniGene

Hs.668596

RefSeq

HUGO

HGNC:16089

OMIM

607735

CCDS

HPRD

09665

IMGT

EMBL

AC096898 AJ002030 AK131272 BC016692 BC092478 CH471056 DQ496105

GenPept

AAH16692 AAH92478 ABF47094 CAA05152 EAX05178 EAX05179 EAX05181