InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPRBP

Summary

InnateDB Protein

IDBP-378706.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPRBP

Protein Name

Vpr (HIV-1) binding protein

Synonyms

DCAF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000393183

InnateDB Gene

IDBG-37403 (VPRBP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.

Experimentally validated
Total	83 [view]
Protein-Protein	83 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:1990244	histone kinase activity (H2A-T120 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0030183	B cell differentiation
GO:0033151	V(D)J recombination
GO:0035212	cell competition in a multicellular organism
GO:1990245	histone H2A-T120 phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008180	COP9 signalosome

Protein Structure and Domains

PDB ID

InterPro

IPR006594 LisH dimerisation motif
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PRINTS

PIRSF

SMART

SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB018343 AC092037 AF061935 AL080145 BC022792 BC110371

GenPept

AAG27134 AAH22792 AAI10372 BAA34520 CAB45738

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca