Version 5.4
Homo sapiens Protein: PHF12
Summary
InnateDB Protein IDBP-37871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF12
Protein Name PHD finger protein 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329933
InnateDB Gene IDBG-37869 (PHF12)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA. {ECO:0000269PubMed:11390640, ECO:0000303PubMed:11390640}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11390640}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001222 transcription corepressor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR001965 Zinc finger, PHD-type
IPR008984 SMAD/FHA domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00498
PF00628
PRINTS
PIRSF
SMART SM00240
SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QT6
PhosphoSite PhosphoSite-Q96QT6
TrEMBL K7ERZ4
UniProt Splice Variant
Entrez Gene 57649
UniGene Hs.743552
RefSeq NP_001028733
HUGO HGNC:20816
OMIM
CCDS CCDS32598
HPRD 15123
IMGT
EMBL AB040956 AC024267 AK024290 AK160370 AY030283 BC001657 BC121044 CH471159
GenPept AAH01657 AAI21045 AAK38349 BAA96047 BAB14875 BAD18713 EAW51166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca