InnateDB Protein
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IDBP-37875.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHF12
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Protein Name
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PHD finger protein 12
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000268756
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InnateDB Gene
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IDBG-37869 (PHF12)
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Protein Structure
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Function |
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA. {ECO:0000269PubMed:11390640, ECO:0000303PubMed:11390640}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11390640}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q96QT6
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PhosphoSite |
PhosphoSite-Q96QT6
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TrEMBL |
K7ERZ4
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UniProt Splice Variant |
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Entrez Gene |
57649
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UniGene |
Hs.743552
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RefSeq |
NP_065940
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HUGO |
HGNC:20816
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OMIM |
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CCDS |
CCDS11247
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HPRD |
15123
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IMGT |
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EMBL |
AB040956
AC024267
AK024290
AK160370
AY030283
BC001657
BC121044
CH471159
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GenPept |
AAH01657
AAI21045
AAK38349
BAA96047
BAB14875
BAD18713
EAW51166
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