InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARP3

Summary

InnateDB Protein

IDBP-378875.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARP3

Protein Name

poly (ADP-ribose) polymerase family, member 3

Synonyms

ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1; PADPRT-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000395951

InnateDB Gene

IDBG-37754 (PARP3)

Protein Structure

UniProt Annotation

Function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269PubMed:16924674}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.

Disease Associations

Tissue Specificity

Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003950	NAD+ ADP-ribosyltransferase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006471	protein ADP-ribosylation
GO:0051106	positive regulation of DNA ligation
GO:0060236	regulation of mitotic spindle organization
GO:1990166	protein localization to site of double-strand break