Version 5.4
Homo sapiens Gene: PARP3
Summary
InnateDB Gene IDBG-37754.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP3
Gene Name poly (ADP-ribose) polymerase family, member 3
Synonyms ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1; PADPRT-3
Species Homo sapiens
Ensembl Gene ENSG00000041880
Encoded Proteins
IDBP-232266
poly (ADP-ribose) polymerase family, member 3
IDBP-378875
poly (ADP-ribose) polymerase family, member 3
IDBP-378877
poly (ADP-ribose) polymerase family, member 3
IDBP-474616
poly (ADP-ribose) polymerase family, member 3
IDBP-474905
poly (ADP-ribose) polymerase family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:51942345-51948867
Strand Forward strand
Band p21.2
Transcripts
ENST00000398755 ENSP00000381740
ENST00000417220 ENSP00000395951
ENST00000431474 ENSP00000401511
ENST00000471971 ENSP00000417396
ENST00000470601
ENST00000470749
ENST00000498510 ENSP00000417625
ENST00000475782
ENST00000486510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003950 NAD+ ADP-ribosyltransferase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006471 protein ADP-ribosylation
GO:0051106 positive regulation of DNA ligation
GO:0060236 regulation of mitotic spindle organization
GO:1990166 protein localization to site of double-strand break
Cellular Component
GO:0005634 nucleus
GO:0005814 centriole
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023249
View Gene Order
ENSBTAG00000000671
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.271742
RefSeq NM_001003931 NM_005485 XM_005264779 XM_006712914
HUGO
OMIM
CCDS CCDS43097 CCDS46839
HPRD 06370
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca