InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCLT1

Summary

InnateDB Protein

IDBP-37919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCLT1

Protein Name

sodium channel and clathrin linker 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281142

InnateDB Gene

IDBG-37917 (SCLT1)

Protein Structure

UniProt Annotation

Function

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:23348840}. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008022	protein C-terminus binding
GO:0017080	sodium channel regulator activity
GO:0030276	clathrin binding

Biological Process

GO:0042384	cilium assembly
GO:0045162	clustering of voltage-gated sodium channels

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0015630	microtubule cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0071439	clathrin complex
GO:0097539	ciliary transition fiber