InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNL3

Summary

InnateDB Protein

IDBP-379583.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNL3

Protein Name

guanine nucleotide binding protein-like 3 (nucleolar)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395772

InnateDB Gene

IDBG-39482 (GNL3)

Protein Structure

UniProt Annotation

Function

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Increased levels in lung tissue in cancer patients. {ECO:0000269PubMed:16012751}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	74 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0008283	cell proliferation
GO:0042127	regulation of cell proliferation
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006073 GTP binding domain
IPR014813 Guanine nucleotide-binding protein-like 3, N-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF08701

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BVP2