InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH3

Summary

InnateDB Protein

IDBP-379623.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH3

Protein Name

cadherin 3, type 1, P-cadherin (placental)

Synonyms

CDHP; HJMD; PCAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000398485

InnateDB Gene

IDBG-38528 (CDH3)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Hypotrichosis congenital with juvenile macular dystrophy (HJMD) [MIM:601553]: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. {ECO:0000269PubMed:11544476, ECO:0000269PubMed:12445216}. Note=The disease is caused by mutations affecting the gene represented in this entry.Ectodermal dysplasia, with ectrodactyly and macular dystrophy (EEM) [MIM:225280]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. {ECO:0000269PubMed:15805154}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in some normal epithelial tissues and in some carcinoma cell lines. {ECO:0000269PubMed:2702654}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding

Biological Process

GO:0001895	retina homeostasis
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007601	visual perception
GO:0010628	positive regulation of gene expression
GO:0010838	positive regulation of keratinocyte proliferation
GO:0022405	hair cycle process
GO:0031424	keratinization
GO:0032773	positive regulation of monophenol monooxygenase activity
GO:0032912	negative regulation of transforming growth factor beta2 production
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045216	cell-cell junction organization
GO:0048023	positive regulation of melanin biosynthetic process
GO:0051796	negative regulation of catagen
GO:0060070	canonical Wnt signaling pathway
GO:0060901	regulation of hair cycle by canonical Wnt signaling pathway
GO:1902910	positive regulation of melanosome transport