Version 5.4
Homo sapiens Gene: CDH3
Summary
InnateDB Gene IDBG-38528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH3
Gene Name cadherin 3, type 1, P-cadherin (placental)
Synonyms CDHP; HJMD; PCAD
Species Homo sapiens
Ensembl Gene ENSG00000062038
Encoded Proteins
IDBP-38532
cadherin 3, type 1, P-cadherin (placental)
IDBP-379623
cadherin 3, type 1, P-cadherin (placental)
IDBP-753389
IDBP-749180
IDBP-745917
IDBP-745542
IDBP-749452
IDBP-750844
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68636189-68722616
Strand Forward strand
Band q22.1
Transcripts
ENST00000264012 ENSP00000264012
ENST00000429102 ENSP00000398485
ENST00000542274 ENSP00000464021
ENST00000568292 ENSP00000463364
ENST00000569080 ENSP00000463415
ENST00000569117
ENST00000567674 ENSP00000463267
ENST00000569036 ENSP00000464058
ENST00000566808 ENSP00000462111
ENST00000565453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005509 calcium ion binding
Biological Process
GO:0001895 retina homeostasis
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007601 visual perception
GO:0010628 positive regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016337 single organismal cell-cell adhesion
GO:0022405 hair cycle process
GO:0031424 keratinization
GO:0032773 positive regulation of monophenol monooxygenase activity
GO:0032912 negative regulation of transforming growth factor beta2 production
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045216 cell-cell junction organization
GO:0048023 positive regulation of melanin biosynthetic process
GO:0051796 negative regulation of catagen
GO:0060070 canonical Wnt signaling pathway
GO:0060901 regulation of hair cycle by canonical Wnt signaling pathway
GO:1902910 positive regulation of melanosome transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061048
View Gene Order
ENSBTAG00000033248
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt P22223
TrEMBL J3KTE9 J3QL75 J3QR34
UniProt Splice Variant
Entrez Gene 1001
UniGene Hs.191842 Hs.629576 Hs.718737
RefSeq NM_001793
HUGO HGNC:1762
OMIM 114021
CCDS CCDS10868
HPRD
IMGT
EMBL AC099314 AC126773 AK312554 BC014462 BC041846 CH471092 X63629 X95824
GenPept AAH14462 AAH41846 BAG35451 CAA45177 CAA65093 EAW83238
RNA Seq Atlas 1001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca