InnateDB Protein
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IDBP-380196.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGEF3
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Protein Name
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Rho guanine nucleotide exchange factor (GEF) 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000410922
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InnateDB Gene
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IDBG-40920 (ARHGEF3)
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Protein Structure
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Function |
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269PubMed:12221096}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. {ECO:0000269PubMed:10873612, ECO:0000269PubMed:12221096}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005089
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Rho guanyl-nucleotide exchange factor activity
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0007266
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Rho protein signal transduction
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0035023
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regulation of Rho protein signal transduction
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GO:0043065
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positive regulation of apoptotic process
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0051056
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regulation of small GTPase mediated signal transduction
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000219
Dbl homology (DH) domain
IPR001849
Pleckstrin homology domain
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PFAM |
PF00621
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00325
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NR81
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PhosphoSite |
PhosphoSite-Q9NR81
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50650
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UniGene |
Hs.608634
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RefSeq |
NP_001122088
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HUGO |
HGNC:683
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OMIM |
612115
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CCDS |
CCDS46855
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HPRD |
12480
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IMGT |
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EMBL |
AB209661
AF249744
AF433662
AK024340
AK291412
AL136832
BC054345
BC068513
BC098122
BC098272
BC099715
BC104723
CH471055
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GenPept |
AAF79954
AAH54345
AAH68513
AAH98122
AAH98272
AAH99715
AAI04724
AAP97313
BAB14891
BAD92898
BAF84101
CAB66766
EAW65326
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