InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF3

Summary

InnateDB Gene

IDBG-40920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF3

Gene Name

Rho guanine nucleotide exchange factor (GEF) 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163947

Encoded Proteins

IDBP-40922

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-40924

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-380196

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-479383

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-476630

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-474275

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-479628

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-485183

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-481767

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-474504

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-478546

Rho guanine nucleotide exchange factor (GEF) 3

IDBP-476212

Rho guanine nucleotide exchange factor (GEF) 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:56727418-57079329

Strand

Reverse strand

Band

p14.3

Transcripts

ENST00000338458	ENSP00000341071
ENST00000296315	ENSP00000296315
ENST00000413728	ENSP00000410922
ENST00000465659	ENSP00000417810
ENST00000496106	ENSP00000420420
ENST00000497267	ENSP00000418826
ENST00000495373	ENSP00000417986
ENST00000468727	ENSP00000417087
ENST00000473779	ENSP00000420402
ENST00000481422
ENST00000498517
ENST00000477833	ENSP00000418984
ENST00000477440
ENST00000468466	ENSP00000418469
ENST00000486829	ENSP00000420633

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway