InnateDB Protein
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IDBP-380254.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBM22
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Protein Name
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RNA binding motif protein 22
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000412118
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InnateDB Gene
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IDBG-53894 (RBM22)
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Protein Structure
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Function |
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269PubMed:17045351, ECO:0000269PubMed:21122810, ECO:0000269PubMed:22246180}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR000571
Zinc finger, CCCH-type
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PFAM |
PF00076
PF00642
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PRINTS |
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PIRSF |
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SMART |
SM00360
SM00356
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NW64
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PhosphoSite |
PhosphoSite-Q9NW64
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55696
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UniGene |
Hs.713564
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RefSeq |
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HUGO |
HGNC:25503
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OMIM |
612430
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CCDS |
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HPRD |
10186
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IMGT |
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EMBL |
AC008453
AK001152
AK297019
AL136933
BC003402
CH471062
U39402
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GenPept |
AAC99998
AAH03402
BAA91521
BAG59551
CAB66867
EAW61711
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