InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HGF

Summary

InnateDB Protein

IDBP-380445.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HGF

Protein Name

hepatocyte growth factor (hepapoietin A; scatter factor)

Synonyms

DFNB39; F-TCF; HGFB; HPTA; SF;

Species

Homo sapiens

Ensembl Protein

ENSP00000391238

InnateDB Gene

IDBG-24150 (HGF)

Protein Structure

UniProt Annotation

Function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269PubMed:15167892, ECO:0000269PubMed:20624990}.

Subcellular Localization

Disease Associations

Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding

Biological Process

GO:0001837	epithelial to mesenchymal transition
GO:0002576	platelet degranulation
GO:0006508	proteolysis
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168	platelet activation
GO:0030335	positive regulation of cell migration
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0060326	cell chemotaxis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane
GO:0031093	platelet alpha granule lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00089
PF00024

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt