InnateDB Protein
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IDBP-380659.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRC1
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Protein Name
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protein regulator of cytokinesis 1
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Synonyms
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ASE1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409549
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InnateDB Gene
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IDBG-30703 (PRC1)
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Protein Structure
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Function |
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. {ECO:0000269PubMed:12082078, ECO:0000269PubMed:15297875, ECO:0000269PubMed:15625105, ECO:0000269PubMed:16431929, ECO:0000269PubMed:19468300, ECO:0000269PubMed:20691902, ECO:0000269PubMed:9885575}.
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Subcellular Localization |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007145
Microtubule-associated protein, MAP65/Ase1/PRC1
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PFAM |
PF03999
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43663
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PhosphoSite |
PhosphoSite-O43663
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TrEMBL |
H0YM42
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UniProt Splice Variant |
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Entrez Gene |
9055
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UniGene |
Hs.641727
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RefSeq |
NP_001254509
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HUGO |
HGNC:9341
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OMIM |
603484
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CCDS |
CCDS45353
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HPRD |
17899
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IMGT |
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EMBL |
AC068831
AF044588
AK297117
BC003138
BC005140
BX647317
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GenPept |
AAC02688
AAH03138
AAH05140
BAG59623
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