InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAT1

Summary

InnateDB Protein

IDBP-380918.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAT1

Protein Name

FAT tumor suppressor homolog 1 (Drosophila)

Synonyms

CDHF7; CDHR8; FAT; hFat1; ME5;

Species

Homo sapiens

Ensembl Protein

ENSP00000406229

InnateDB Gene

IDBG-47783 (FAT1)

Protein Structure

UniProt Annotation

Function

Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15922730}; Single-pass type I membrane protein {ECO:0000269PubMed:15922730}. Nucleus {ECO:0000269PubMed:15922730}. Cytoplasm, perinuclear region {ECO:0000269PubMed:15922730}.

Disease Associations

Tissue Specificity

Expressed in many epithelial and some endothelial and smooth muscle cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0007267	cell-cell signaling
GO:0009653	anatomical structure morphogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like

PFAM

PF00008
PF00054
PF02210
PF07645
PF00028

PRINTS

PR00205

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179
SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt