Version 5.4
Homo sapiens Gene: FAT1
Summary
InnateDB Gene IDBG-47783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAT1
Gene Name FAT tumor suppressor homolog 1 (Drosophila)
Synonyms CDHF7; CDHR8; FAT; hFat1; ME5
Species Homo sapiens
Ensembl Gene ENSG00000083857
Encoded Proteins
IDBP-380918
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-475735
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-475308
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-484751
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-477142
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-473838
FAT tumor suppressor homolog 1 (Drosophila)
IDBP-811042
FAT atypical cadherin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:186587783-186726722
Strand Reverse strand
Band q35.2
Transcripts
ENST00000441802 ENSP00000406229
ENST00000500085
ENST00000512772 ENSP00000424157
ENST00000507105 ENSP00000423801
ENST00000509537 ENSP00000421003
ENST00000509927 ENSP00000420869
ENST00000507662
ENST00000512347
ENST00000503253
ENST00000508035
ENST00000509647 ENSP00000423736
ENST00000614102 ENSP00000479573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007267 cell-cell signaling
GO:0009653 anatomical structure morphogenesis
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070047
View Gene Order
ENSBTAG00000020657
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14517
TrEMBL D6RCE4 D6RHE6 H0Y8F5
UniProt Splice Variant
Entrez Gene 2195
UniGene Hs.481371 Hs.695173
RefSeq NM_005245 XM_005262835 XM_006714139
HUGO HGNC:3595
OMIM 600976
CCDS CCDS47177
HPRD
IMGT
EMBL AC107050 AC110761 X87241
GenPept CAA60685
RNA Seq Atlas 2195

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca