InnateDB Protein
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IDBP-381103.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLCO2B1
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Protein Name
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solute carrier organic anion transporter family, member 2B1
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Synonyms
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OATP-B; OATP2B1; OATPB; SLC21A9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389653
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InnateDB Gene
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IDBG-64595 (SLCO2B1)
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Protein Structure
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Function |
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver. {ECO:0000269PubMed:23531488}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005215
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transporter activity
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GO:0008514
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organic anion transmembrane transporter activity
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GO:0015347
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sodium-independent organic anion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004156
Organic anion transporter polypeptide OATP
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF03137
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O94956
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PhosphoSite |
PhosphoSite-O94956
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TrEMBL |
B4DJH3
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UniProt Splice Variant |
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Entrez Gene |
11309
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UniGene |
Hs.7884
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RefSeq |
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HUGO |
HGNC:10962
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OMIM |
604988
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CCDS |
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HPRD |
07061
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IMGT |
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EMBL |
AB020687
AB026256
AF205073
AK290234
AK294503
AK296079
AK300134
AL117465
AP001972
BC041095
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GenPept |
AAG42205
AAH41095
BAA74903
BAA78638
BAF82923
BAG57720
BAG58835
BAG61922
CAB55940
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