Homo sapiens Protein: NFYC
Summary
InnateDB Protein IDBP-381428.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFYC
Protein Name nuclear transcription factor Y, gamma
Synonyms CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC;
Species Homo sapiens
Ensembl Protein ENSP00000396620
InnateDB Gene IDBG-96999 (NFYC)
Protein Structure
UniProt Annotation
Function Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006457 protein folding
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016602 CCAAT-binding factor complex
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13952
PhosphoSite PhosphoSite-Q13952
TrEMBL Q5T6K7
UniProt Splice Variant
Entrez Gene 4802
UniGene Hs.626316
RefSeq NP_001136060
HUGO HGNC:7806
OMIM 605344
CCDS CCDS44120
HPRD
IMGT
EMBL AB208975 AC119677 AF191744 AK000346 AK127677 AK300774 AK301385 AL031289 AL354914 BC005003 BT020081 CH471059 D85425 D89986 U62296 U78774 Z70024 Z74792
GenPept AAC50816 AAC51669 AAG28389 AAH05003 AAV38884 BAA12818 BAA14051 BAA91100 BAD92212 BAG54549 BAG62438 BAG62925 CAA93846 CAA99055 CAI16530 CAI16531 CAI16532 CAI16533 EAX07198 EAX07201 EAX07202 EAX07203