InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFYC

Summary

InnateDB Protein

IDBP-381435.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYC

Protein Name

nuclear transcription factor Y, gamma

Synonyms

CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC;

Species

Homo sapiens

Ensembl Protein

ENSP00000408315

InnateDB Gene

IDBG-96999 (NFYC)

Protein Structure

UniProt Annotation

Function

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	39 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006457	protein folding
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process