InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PVR

Summary

InnateDB Protein

IDBP-381602.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVR

Protein Name

poliovirus receptor

Synonyms

CD155; HVED; Necl-5; NECL5; PVS; TAGE4;

Species

Homo sapiens

Ensembl Protein

ENSP00000402060

InnateDB Gene

IDBG-56486 (PVR)

Protein Structure

UniProt Annotation

Function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269PubMed:15471548, ECO:0000269PubMed:15607800}.

Subcellular Localization

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.Isoform Delta: Cell membrane; Single-pass type I membrane protein.Isoform Beta: Secreted.Isoform Gamma: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0009615	response to virus
GO:0016032	viral process
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity
GO:0045216	cell-cell junction organization
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050776	regulation of immune response
GO:0060370	susceptibility to T cell mediated cytotoxicity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15151