InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PVR

Summary

InnateDB Gene

IDBG-56486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVR

Gene Name

poliovirus receptor

Synonyms

CD155; HVED; Necl-5; NECL5; PVS; TAGE4

Species

Homo sapiens

Ensembl Gene

ENSG00000073008

Encoded Proteins

IDBP-56488

poliovirus receptor

IDBP-56490

poliovirus receptor

IDBP-294368

poliovirus receptor

IDBP-294367

poliovirus receptor

IDBP-381602

poliovirus receptor

IDBP-760075

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44643798-44663583

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000187830	ENSP00000187830
ENST00000344956	ENSP00000340870
ENST00000403059	ENSP00000385344
ENST00000406449	ENSP00000383907
ENST00000425690	ENSP00000402060
ENST00000587785	ENSP00000466447

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0009615	response to virus
GO:0016032	viral process
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity
GO:0045216	cell-cell junction organization
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050776	regulation of immune response
GO:0060370	susceptibility to T cell mediated cytotoxicity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome