Homo sapiens Gene: PVR
Summary
InnateDB Gene IDBG-56486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PVR
Gene Name poliovirus receptor
Synonyms CD155; HVED; Necl-5; NECL5; PVS; TAGE4;
Species Homo sapiens
Ensembl Gene ENSG00000073008
Encoded Proteins
poliovirus receptor
poliovirus receptor
poliovirus receptor
poliovirus receptor
poliovirus receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:44643798-44663583
Strand Forward strand
Band q13.31
Transcripts
ENST00000187830 ENSP00000187830
ENST00000344956 ENSP00000340870
ENST00000403059 ENSP00000385344
ENST00000406449 ENSP00000383907
ENST00000425690 ENSP00000402060
ENST00000587785 ENSP00000466447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0009615 response to virus
GO:0016032 viral process
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity
GO:0045216 cell-cell junction organization
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
GO:0060370 susceptibility to T cell mediated cytotoxicity
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Nectin/Necl trans heterodimerization pathway
Cell-Cell communication pathway
Cell junction organization pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID BIOCARTA
PID NCI
Nectin adhesion pathway
Beta3 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619496
RefSeq NM_001135768 NM_001135769 NM_001135770 NM_006505
HUGO
OMIM
CCDS CCDS12640 CCDS46105 CCDS46106 CCDS46107
HPRD 01434
IMGT
EMBL
GenPept
RNA Seq Atlas