InnateDB Protein
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IDBP-381657.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ODF2
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Protein Name
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outer dense fiber of sperm tails 2
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Synonyms
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CT134; ODF2/1; ODF2/2; ODF84;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396687
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InnateDB Gene
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IDBG-88092 (ODF2)
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Protein Structure
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Function |
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269PubMed:16966375}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.
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Disease Associations |
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Tissue Specificity |
Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails. {ECO:0000269PubMed:10381817}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5BJF6
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PhosphoSite |
PhosphoSite-Q5BJF6
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TrEMBL |
Q9UNM2
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UniProt Splice Variant |
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Entrez Gene |
4957
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UniGene |
Hs.129055
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RefSeq |
NP_001229283
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HUGO |
HGNC:8114
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OMIM |
602015
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CCDS |
CCDS56589
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HPRD |
03601
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IMGT |
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EMBL |
AF012549
AF053970
AF109138
AK299303
AK301842
AK302684
AL359091
AL445287
AY319414
AY366499
BC010629
BC091500
CH471090
DQ444713
DQ444714
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GenPept |
AAB66337
AAC08409
AAD22544
AAH10629
AAH91500
AAP83847
AAQ73195
ABE01856
ABE01857
BAG61316
BAG63285
BAG63914
CAH71066
CAH71067
CAH71069
CAI13499
CAI13500
CAI13506
EAW87791
EAW87793
EAW87795
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