Homo sapiens Gene: ODF2
Summary
InnateDB Gene IDBG-88092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ODF2
Gene Name outer dense fiber of sperm tails 2
Synonyms CT134; ODF2/1; ODF2/2; ODF84;
Species Homo sapiens
Ensembl Gene ENSG00000136811
Encoded Proteins
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as \'Cenexins\', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:128455186-128501292
Strand Forward strand
Band q34.11
Transcripts
ENST00000372814 ENSP00000361901
ENST00000351030 ENSP00000342581
ENST00000372807 ENSP00000361893
ENST00000372791 ENSP00000361877
ENST00000393533 ENSP00000377166
ENST00000393527 ENSP00000377161
ENST00000448249 ENSP00000396687
ENST00000444993
ENST00000421776 ENSP00000395489
ENST00000444119 ENSP00000394506
ENST00000434106 ENSP00000403453
ENST00000446274 ENSP00000415290
ENST00000432065 ENSP00000407852
ENST00000469582
ENST00000497812 ENSP00000474949
ENST00000470061 ENSP00000475118
ENST00000483070 ENSP00000474651
ENST00000488909
ENST00000546203 ENSP00000437579
ENST00000604420 ENSP00000473949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
Cellular Component
GO:0000922 spindle pole
GO:0001520 outer dense fiber
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005929 cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID BIOCARTA
PID NCI
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.129055
RefSeq NM_001242352 NM_001242353 NM_001242354 NM_002540 NM_153432 NM_153433 NM_153435 NM_153436 NM_153437 NM_153439 NM_153440 XM_005252010 XM_005252022 XM_006717123 XM_006717125 XM_006717126
HUGO
OMIM
CCDS CCDS56585 CCDS56586 CCDS56587 CCDS56588 CCDS56589 CCDS56590 CCDS6902
HPRD 03601
IMGT
EMBL
GenPept
RNA Seq Atlas