Version 5.4
| Homo sapiens Gene: ODF2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-88092.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ODF2 | ||||||||||||||||||
| Gene Name | outer dense fiber of sperm tails 2 | ||||||||||||||||||
| Synonyms | CT134; ODF2/1; ODF2/2; ODF84 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000136811 | ||||||||||||||||||
| Encoded Proteins |
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
outer dense fiber of sperm tails 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010] The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as \'Cenexins\', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 9:128455186-128501292 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q34.11 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
PLK1 signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | Q5BJF6 | ||||||||||||||||||
| TrEMBL | Q5T4C7 Q6PJQ8 Q9UNM2 S4R462 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 4957 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001242353 NM_001242352 NM_001242354 NM_002540 NM_153432 NM_153433 NM_153435 NM_153436 NM_153437 NM_153439 NM_153440 XM_005252010 XM_005252022 XM_006717123 XM_006717125 XM_006717126 | ||||||||||||||||||
| HUGO | HGNC:8114 | ||||||||||||||||||
| OMIM | 602015 | ||||||||||||||||||
| CCDS | CCDS56588 CCDS56585 CCDS56586 CCDS56587 CCDS56589 CCDS56590 CCDS6902 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF012549 AF053970 AF109138 AK299303 AK301842 AK302684 AL359091 AL445287 AY319414 AY366499 BC010629 BC012785 BC091500 CH471090 DQ444713 DQ444714 | ||||||||||||||||||
| GenPept | AAB66337 AAC08409 AAD22544 AAH10629 AAH12785 AAH91500 AAP83847 AAQ73195 ABE01856 ABE01857 BAG61316 BAG63285 BAG63914 CAH71066 CAH71067 CAH71069 CAI13499 CAI13500 CAI13506 EAW87791 EAW87793 EAW87795 | ||||||||||||||||||
| RNA Seq Atlas | 4957 | ||||||||||||||||||