InnateDB Protein
|
IDBP-381816.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RBMX
|
Protein Name
|
RNA binding motif protein, X-linked
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000411989
|
InnateDB Gene
|
IDBG-87732 (RBMX)
|
Protein Structure
|
|
Function |
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269PubMed:12165565, ECO:0000269PubMed:12761049, ECO:0000269PubMed:16707624, ECO:0000269PubMed:18445477, ECO:0000269PubMed:18541147, ECO:0000269PubMed:19282290, ECO:0000269PubMed:21327109}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:19282290, ECO:0000269PubMed:21327109}. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
|
Disease Associations |
|
Tissue Specificity |
Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). {ECO:0000269PubMed:16707624}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
110
[view]
|
Protein-Protein |
110
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0000381
|
regulation of alternative mRNA splicing, via spliceosome
|
GO:0000398
|
mRNA splicing, via spliceosome
|
GO:0001649
|
osteoblast differentiation
|
GO:0006366
|
transcription from RNA polymerase II promoter
|
GO:0006509
|
membrane protein ectodomain proteolysis
|
GO:0008380
|
RNA splicing
|
GO:0010467
|
gene expression
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0048025
|
negative regulation of mRNA splicing, via spliceosome
|
GO:0048026
|
positive regulation of mRNA splicing, via spliceosome
|
GO:0051260
|
protein homooligomerization
|
GO:0071347
|
cellular response to interleukin-1
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000504
RNA recognition motif domain
|
PFAM |
PF00076
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P38159
|
PhosphoSite |
PhosphoSite-P38159
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
27316
|
UniGene |
Hs.711556
|
RefSeq |
NP_001158275
|
HUGO |
HGNC:9910
|
OMIM |
300199
|
CCDS |
CCDS55510
|
HPRD |
02186
|
IMGT |
|
EMBL |
AF266720
AF266721
AF266722
AF266723
AK096015
AK304868
AL683813
AY464692
BC006550
BC007435
CH471150
Z23064
|
GenPept |
AAH06550
AAH07435
AAK58567
AAR28036
BAC04674
BAG65606
CAA80599
CAI39448
EAW88453
EAW88454
EAW88455
EAW88457
|
|
|