Version 5.4
Homo sapiens Gene: RBMX
Summary
InnateDB Gene IDBG-87732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBMX
Gene Name RNA binding motif protein, X-linked
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147274
Encoded Proteins
IDBP-87734
RNA binding motif protein, X-linked
IDBP-381813
RNA binding motif protein, X-linked
IDBP-381816
RNA binding motif protein, X-linked
IDBP-713225
IDBP-713595
IDBP-713034
IDBP-713079
IDBP-713310
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009] Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box C/D class snoRNAs are involved in site-specific 2-prime-O-ribose methylation of preribosomal RNA precursors. This snoRNA is located in an intron of the RNA binding motif protein, X-linked gene (RBMX). [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:136848004-136880764
Strand Reverse strand
Band q26.3
Transcripts
ENST00000320676 ENSP00000359645
ENST00000419968 ENSP00000405117
ENST00000431446 ENSP00000411989
ENST00000496459
ENST00000464781 ENSP00000456048
ENST00000561733
ENST00000565438 ENSP00000457866
ENST00000562646 ENSP00000457051
ENST00000568578 ENSP00000457691
ENST00000565907
ENST00000563370 ENSP00000454777
ENST00000567262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
Experimentally validated
Total 110 [view]
Protein-Protein 110 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001047 core promoter binding
GO:0003676 nucleic acid binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0001649 osteoblast differentiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006509 membrane protein ectodomain proteolysis
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0051260 protein homooligomerization
GO:0071347 cellular response to interleukin-1
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005719 nuclear euchromatin
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0044530 supraspliceosomal complex
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031134
View Gene Order
ENSBTAG00000013308
Not yet available
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BT71
UniProt Splice Variant
Entrez Gene 27316
UniGene Hs.380118 Hs.628400 Hs.676488 Hs.711556
RefSeq NM_001164803 NM_002139
HUGO HGNC:9910
OMIM 300199
CCDS CCDS14661 CCDS55510
HPRD 02186
IMGT
EMBL AL683813
GenPept
RNA Seq Atlas 101928747 26787 27316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca