InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBC1D4

Summary

InnateDB Protein

IDBP-38220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBC1D4

Protein Name

TBC1 domain family, member 4

Synonyms

AS160;

Species

Homo sapiens

Ensembl Protein

ENSP00000366863

InnateDB Gene

IDBG-38218 (TBC1D4)

Protein Structure

UniProt Annotation

Function

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269PubMed:15971998, ECO:0000269PubMed:18771725, ECO:0000269PubMed:22908308}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18771725}. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

Disease Associations

Tissue Specificity

Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. {ECO:0000269PubMed:15304337, ECO:0000269PubMed:18276765, ECO:0000269PubMed:18771725}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0016192	vesicle-mediated transport
GO:0031339	negative regulation of vesicle fusion
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0032869	cellular response to insulin stimulus
GO:0061024	membrane organization